Cryogenic Labels for ultra-low temperature storage Covid -19 vaccines and cold chain logistics
Why need the development of Cryogenic Labels?
The low-level temperatures needed for delivery of the breakthrough COVID-19 vaccines have spotlighted the cold pharmaceutical chain. Still, the need for ultra-low temperature solutions has been steadily rising alongside the development of advanced biologics and genetic therapeutics.
Withstand against low-level temperatures
Highly durable, cold-resistant labels are essential to the process of bringing these advanced therapeutics to the market. Labeling the materials required to withstand the low-level temperatures of dry ice and liquid nitrogen as the samples and compounds are shipped between laboratories and research centers.
Adhere to any design of vials
These Labels must reliably adhere to the numerous small, curved vials used throughout clinical trials. They want to provide a print quality that ensures the readability of critical knowledge of progress to distribution.
Range of cryogenic labels for Covid-19 vaccines
Avery Dennison’s’ range of labels for cryogenic and dry ice forms offered durable solutions for the pharmaceutical industries. The portfolio includes labeling solutions for application temperatures as low as -50°C, as well as solutions for high-speed production lines currently being used to label Covid-19 vaccines.
Explicitly designed to meet industry challenges, Avery Dennison’s cryogenic range provides solutions that have an ultra-low service temperature, adhere firmly to rounded vials, and reliably display variable knowledge, ultimately that value chain.
Cryogenic labels for frozen surfaces
Pharmaceutical discovery areas frequently require ultra-low temperatures for storage and shipping, often using dry ice (-80°C) or liquid nitrogen (-196°C). Cold chain and cryogenic logistics play a crucial function in innovations such as nucleic acid vaccines, the 1000+ clinical trials currently undertaken for cell and gene therapies (CGTs), and the bio-banking required to preserve genetic data 52 million genomes expected to be sequenced by 2025.
Secure labeling is critical for effectiveness and safety in the research, development, and even delivery of these breakthrough therapeutics. All explanations in Avery Dennison’s cryogenic range (Cryogenic labels for frozen surfaces) have a service temperature range of -196°C to +120°C, giving a secure bond in ultra-low temperatures.
In particular situations, there is also a necessity for labels to have ultra-low application temperatures, labeling samples in clinical experiments that cannot risk temperature variations. The vast majority of pressure-sensitive labels cannot stick to containers’ frozen surfaces due to loss of tack as the adhesive instantly solidifies on contact.
C2050P adhesive – Cryogenic labels for frozen surfaces
Avery Dennison’s breakthrough C2050P adhesive is the primary adhesive on the market, capable of being applied at -50°C. It performs reliable labeling solutions with fewer temperature changes for vaccine construction, plasma processing, clinical trials, bio-banking, and more.
Stable adhesion to small, curved vials
Vials, test tubes, vacuettes, and other pharmaceutical container often have a small diameter and a high curvature. Even in room temperatures, usual adhesives have difficulty giving a strong enough mandrel hold and the capability to adhere to curved surfaces without “winging up” at the sides for those vessels. If the label begins to shear away in ultra-low temperatures, the edges freeze, become rigid, and are prone to snapping.
The facestocks ready in Avery Dennison’s cryogenic range are incredibly conformable. Combined with a cryogenic adhesive, they offer a strong mandrel hold that makes them excellent for ultra-low temperature applications, including plastics, glass, steel, and aluminum.
For high scale applications, a label’s mandrel hold must be stable across industrial production processes. Avery Dennison’s S2196 adhesive has been rigorously examined to ensure a firm grip when applied in high-speed production lines and stored at ultra-low temperatures. Labeling clarifications made with S2196 are currently qualified and in use in select Covid-19 vaccine distribution efforts.
Clear and reliable variable information display
The primary purpose of a label is to share information along the value chain reliably. It should be comfortable and easy to print or write data on a label. This print quality should be robust so that information is clear. The label should withstand any frost or concentration if the container is taken out of the freezer.
Materials in Avery Dennison’s cryogenic range are cooperative with various variable information printing techniques, included thermal transference, UV Inkjet, dry toner, and even manually writing data with a pen. The portfolio allows applications that need to withstand multiple freeze-thaw cycles, autoclave sterilization, and harsh chemicals to classify samples, ultimately the value chain.
The broad portfolio for custom cold chain solutions
The Avery Dennison’s cryogenic range of labels has been designed, especially for applications that leverage deep freezing, dry ice, and liquid nitrogen. Complete solutions in this portfolio have a service temperature range of -196°C to +120°C.
Cryogenic storage labels – S2196
Two advanced adhesives are the foundational ingredient of this portfolio. S2196 is an adhesive best for industrial generation and large-scale, high-speed applications before-mentioned as vaccine labeling. C2050P is the single adhesive on the market with an application temperature as low as -50°C and is most suitable for manual application in low temperatures, such as clinical trial samples.
These adhesives can be connected with a selection of white and clear facestock to provide a labeling solution tailored to printability requirements, sterilization, chemical resistance, and vessel size.
The cryogenic area is part of Avery Dennison’s broad portfolio of cold chain explanations explicitly designed for the most demanding pharma and healthcare applications. That portfolio includes innovations ranging from blood bag statements to temperature sensors to cost-effective encapsulated vacuum insulation panels.
If you are excited about reading more about cold chain labeling solutions, explore the product guide and click the button below to start a conversation with Benoit Jourde, Avery Dennison’s expert in pharmaceutical and healthcare labels, to determine the materials best suited for your needs.
